NS 490
Manipulating the Mouse Genome (also BIOGD 490[4900])
Fall. 1 credit. Meets during first half of semester and provides background information for VTBMS/TOX 701 Mouse Pathology and Transgenesis, which meets during second half. Students interested in both must register for them separately. Prerequisites: BIOGD 280, 281, or 282 and BIOBM 330, 332 or 333, or NS 320. S-U or letter grades. P. Soloway.
Functional genomic analysis has benefited enormously from experimental manipulation of the genomes of many organisms. The mouse has been the model of choice for such studies in mammals. Explores the tools available for experimental manipulation of the mouse genome, including transgenesis, gene targeting, gene trapping, chemical mutagenesis, and cloning by nuclear transplant. Also discussed are use of recombinant inbred mice for complex trait analysis. Readings from the scientific literature focus on seminal applications of these methods.